About/CV
I am currently a Senior Scientist and Head of Department at the Dasman Diabetes Institute (Kuwait). I am also a tenured INSERM Researcher (CRCN) at the Immunity and Metabolism of Diabetes (IMMEDIAB) team (Paris, France).
My projects investigate the mechanisms by the immune system influences or adapts to the changes associated with diabetes. Our goal is to discover novel therapeutic targets to influence disease progression.
Professional Experience
Current position: Senior Scientist - Head of Department, Dasman Diabetes Institute, Kuwait (since 2022) and Research Associate (CRCN) INSERM, Paris, France (since 2017)
2014 - 2017: Post-doctoral fellow, INSERM, Paris, France
2012 - 2014, Visiting Scientist (Post-doctoral), King's College London/University of Westminster, London, United Kingdom
Education
HDR Health and Life Sciences - Sorbonne Université - 2021 [Habilitation à Diriger des Recherches]
PhD Nutrition - King's College London - 2012
MSc Nutrition, Physical Activity and Public Health - University of Westminster - 2008
BSc (Hons) Human Nutrition - University of Westminster - 2007
Publications
Orliaguet et al 2022. Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling. Nat Commun.
Thibaut et al 2022. Liver macrophages and inflammation in physiology and physiopathology of non-alcoholic fatty liver disease. FEBS J.
Thibaut et al 2022. Perspective on direction of control: Cellular metabolism and macrophage polarization. Front Immunol.
Kochumon et al 2022. Increased Adipose Tissue Expression of IL-23 Associates with Inflammatory Markers in People with High LDL Cholesterol. Cells
Al-Sayyar et al 2022. Respiratory Tract Infections in Diabetes - Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity. Front. Endocrinol.
Akhter et al 2022. IFN-gamma and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation. J Inflamm Res.
Thibaut et al 2021. [Elongase 2 and polyunsaturated fatty acids: Key players in inflammation and type 2 diabetes]. Med Sci (Paris).
Drareni et al 2020. Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion. Cell Rep.
Alzaid et al 2020. Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID-19 in type 2 diabetes. EMBO Mol Med.
Orliaguet et al 2020. Metabolic and Molecular Mechanisms of Macrophage Polarisation and Adipose Tissue Insulin Resistance. Int J Mol Sci.
Renaudin et al 2020. Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1-beta activation on macrophages. Ann Rheum Dis.
Orliaguet et al 2020. Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity. Front Endocrinol.
Brial et al 2020. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances beta-Cell Function. Cell Rep.
Gaborit et al 2020. Glucagon-like Peptide 1 Receptor Agonists, Diabetic Retinopathy and Angiogenesis: The AngioSafe Type 2 Diabetes Study. J Clin Endocrinol Metab.
Drareni et al 2019. Transcriptional control of macrophage polarisation in type 2 diabetes. Semin Immunopathol.
Liang et al 2019. Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPAR-alpha. Nat Commun.
Brial et al 2019. Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment. Sci Rep.
Julla et al 2019. Isolation and Analysis of Human Monocytes and Adipose Tissue Macrophages. Methods Mol Biol.
Das et al 2019. Regulatory T Cells under the Mercy of Mitochondria. Cell Metab.
Drareni et al 2018. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Rep.
Laurans et al 2018. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nat Med.
de Jong et al 2018. Functional and phenotypical analysis of IL-6-secreting CD4(+) T cells in human adipose tissue. Eur J Immunol.
Firmin et al 2017. The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPAR-gamma. Sci Rep.
Naufahu et al 2017. Melanin-concentrating hormone in peripheral circulation in the human. J Endocrinol.
Alzaid et al 2016. IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. JCI Insight.
Fan et al 2016. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nat Med.
Dalmas et al 2015. Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity. Nat Med.
Alzaid et al 2013. Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS One.